@article {269916,
	title = {Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity},
	journal = {AIDS Res Hum RetrovirusesAIDS Res Hum RetrovirusesAIDS Res Hum Retroviruses},
	volume = {27},
	year = {2011},
	note = {Pendyala, GuruduttTrauger, Sunia ASiuzdak, GaryFox, Howard SP01 DA026146/DA/NIDA NIH HHS/P30 MH062261/MH/NIMH NIH HHS/R01 MH073490/MH/NIMH NIH HHS/R01 MH073490-01/MH/NIMH NIH HHS/R01 MH073490-02/MH/NIMH NIH HHS/R01 MH073490-03/MH/NIMH NIH HHS/R01 MH073490-04/MH/NIMH NIH HHS/R01 MH073490-05/MH/NIMH NIH HHS/R01 MH073490-06/MH/NIMH NIH HHS/AIDS Res Hum Retroviruses. 2011 Feb;27(2):179-82. doi: 10.1089/aid.2010.0090. Epub 2010 Oct 7.},
	month = {Feb},
	pages = {179-82},
	type = {Research Support, N.I.H., Extramural},
	edition = {2010/10/12},
	abstract = {The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antioxidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.},
	keywords = {*Oxidative Stress, *Proteomics, Animals, Blood Proteins/*metabolism, Chronic Disease, Humans, Methamphetamine/*administration \& dosage, Simian Acquired Immunodeficiency Syndrome/*blood},
	isbn = {1931-8405 (Electronic)0889-2229 (Linking)},
	author = {Pendyala, G. and Trauger, S. A. and Siuzdak, G. and Fox, H. S.}
}
