HOME / PUBLICATIONS /

Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity

Date Published:

Feb

Abstract:

The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antioxidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.

Notes:

Pendyala, GuruduttTrauger, Sunia ASiuzdak, GaryFox, Howard SP01 DA026146/DA/NIDA NIH HHS/P01 DA026146-01/DA/NIDA NIH HHS/P01 DA026146-010002/DA/NIDA NIH HHS/P01 DA026146-019001/DA/NIDA NIH HHS/P01 DA026146-02/DA/NIDA NIH HHS/P01 DA026146-020002/DA/NIDA NIH HHS/P01 DA026146-029001/DA/NIDA NIH HHS/P01 DA026146-03/DA/NIDA NIH HHS/P30 MH062261/MH/NIMH NIH HHS/P30 MH062261-01/MH/NIMH NIH HHS/P30 MH062261-02/MH/NIMH NIH HHS/P30 MH062261-03/MH/NIMH NIH HHS/P30 MH062261-04/MH/NIMH NIH HHS/P30 MH062261-05/MH/NIMH NIH HHS/P30 MH062261-05S1/MH/NIMH NIH HHS/P30 MH062261-06A1/MH/NIMH NIH HHS/P30 MH062261-06A19008/MH/NIMH NIH HHS/P30 MH062261-079008/MH/NIMH NIH HHS/P30 MH062261-089008/MH/NIMH NIH HHS/P30 MH062261-097599/MH/NIMH NIH HHS/P30 MH062261-107599/MH/NIMH NIH HHS/R01 MH073490/MH/NIMH NIH HHS/R01 MH073490-01/MH/NIMH NIH HHS/R01 MH073490-02/MH/NIMH NIH HHS/R01 MH073490-03/MH/NIMH NIH HHS/R01 MH073490-04/MH/NIMH NIH HHS/R01 MH073490-05/MH/NIMH NIH HHS/R01 MH073490-06/MH/NIMH NIH HHS/AIDS Res Hum Retroviruses. 2011 Feb;27(2):179-82. Epub 2010 Oct 7.

Website