Please make sure that your samples are completely in-solution before analysis on ESI-TOF or any LC-MS instrument. Centrifuge at 14000 g to remove any possible solids. Any particulate matter will clog the small inner diameter transfer lines, injector etc. and cause maintenance down time. Spinning using a high speed ultracentrifuge and transferring the supernatant should be used to remove solids.
April 30, 2013