The Facility will be closed over the holidays between December 25-January 1. January 24th is a half day and most of the staff will leave around mid-day. Please note some of the staff may be on vacation a little earlier so check with us by email before coming over.
All staff will be out the rest of the week. As always, the open access lab is open for use 24/7 for authorized users who have obtained card access. However, if the instruments malfunction, we will not be able to assist you! Happy Thanksgiving!
Instrument was vented today 11/26/13, and thoroughly cleaned inside, and glass capillary interface replaced by our Agilent engineer, Gina. It was very dirty and this was not only reducing sensitivity but also causing periodic shorting of the capillary that gives the Analyzer Board error. There was also partial clogging of the column switching valve in the column compartment. The tubing was re-configured to be like factory layout. It should not affect how you run your experiments.
Due to heavy use of the Agilent ESI-TOF, some people were not able to run their quick direct injection experiments on certain days. While many of you would probably like a dedicated "open access" instrument, this is not possible or an efficient use of the instrument, since on some days, no one runs their samples. Our alternate solution, I believe will assure a more efficient use of the instrument, while still allowing people to run their quick samples daily.
Congratulations to Henry Haiser, Peter Turnbaugh and our own Kelly Chatman for their manuscript in the journal Science entitled "Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta". Kelly's project with Henry involved the targeted quantification of the cardiac drug digoxin, and its metabolites to discover how differences in gut microbiome can affect drug metabolism (Science, July 19th 2013, Vol. 341, 6143, pp. 295-298).